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Tag: milrinone

Use of Milrinone in Critically Ill Children: DISCUSSION part 3

Limitations This study had several limitations. The short time frame (6 months) did not allow analysis of temporal trends in milrinone use. The use of logistic regression, which focuses on the presence or absence of an event, prevented us from capturing the time course (i.e., onset, frequency, duration) of outcomes. The time course of independent […]

Use of Milrinone in Critically Ill Children: DISCUSSION part 2

Association of Milrinone Dosing with Efficacy Despite the fact that for most admissions (80.3%) the patient started milrinone before admission to the CCU, low cardiac output syndrome during the CCU stay was common (76.1%). This frequency was nearly twice the 45% reported in the Prophylactic Intravenous Use of Milrinone after Cardiac Operation in Pediatrics (PRIMACORP) […]

Use of Milrinone in Critically Ill Children: DISCUSSION

This retrospective study involved a cohort of 197 patients representing 213 admissions to the CCU over a 6-month peri­od. The median initial loading dose was 99.2 Hg/kg, and the median infusion rate was 0.64 Hg/kg per minute for a median duration of 43.1 hours. Milrinone duration was significantly associated with low cardiac output syndrome, but […]

Use of Milrinone in Critically Ill Children: RESULTS part 2

Concomitant Medications The most commonly used vasoactive drugs were dopamine (94 admissions [44.1%]) and epinephrine (32 [15.0%]), followed by vasopressin (22 [10.3%]) and phenoxy- benzamine (13 [6.1%). Nephrotoxic medications (including aminoglycosides, vancomycin, acyclovir, ganciclovir, ampho- tericin, cidofovir, cyclosporine, tacrolimus, and sirolimus) were used in 58 (27.2%) of the admissions. Anticoagulants and platelet-lowering drugs (unfractionated heparin, […]

Use of Milrinone in Critically Ill Children: RESULTS

A total of 202 potentially eligible patients were identified. Of these, 197 received milrinone in the CCU between January 5 and June 19, 2004; an additional 5 patients who had received milrinone in the operating room but not the CCU were excluded from the study (Figure 1). Of the patients included in the study, 12 […]

Use of Milrinone in Critically Ill Children: Statistical Analysis

Descriptive data were summarized as means, standard devi­ations, and medians for continuous variables and proportions for categorical variables. Univariate analysis between categorical independent variables and each outcome was performed by means of 2 x 2 contingency tables. Variables having statistically significant correlation with the outcomes (p < 0.05) according to the Fisher exact test were […]

Use of Milrinone in Critically Ill Children: METHODS

A retrospective evaluation was performed in a cohort of consecutive patients. Patients admitted to the pediatric Critical Care Unit (CCU) ofThe Hospital for Sick Children starting in January 2004 who received milrinone intravenously were eligible for inclusion. There were no exclusion criteria, which allowed patients with a variety of indications to be included in the […]