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Tag: metabolic alkalosis

Alterations in Acid-Base Homeostasis with Aging: METABOLIC ALKALOSIS

An increase in plasma bicarbonate concentration and an increase in blood pH characterize metabolic alkalosis. A mixed disturbance of metabolic alkalosis and metabolic acidosis can be diagnosed by a significantly increased anion gap in the presence of a normal or near-normal serum pH. Metabolic alkalosis can result from ECF hydrogen ion loss, the addition of […]

Alterations in Acid-Base Homeostasis with Aging: METABOLIC ACIDOSIS

Metabolic acidosis is a process that results in excessive generation of H+ or consumption of serum HCO3. It may or may not be associated with acidemia (low plasma pH). This can occur by the addition of an acid, direct loss of bicarbonate from the gastrointestinal tract or the kidney, or rapid dilution of the ECF […]

Alterations in Acid-Base Homeostasis with Aging: ACID-BASE DISORDERS

Serum [H+] is maintained within a narrow range through a series of reversible chemical buffers and physiologic pulmonary and renal responses. Although the pH of the extracellular fluid (ECF) is maintained between 7.38-7.42 in the elderly, there is evidence to suggest this occurs at the expense of a reduced serum НСОз reserve. A recent review […]

Alterations in Acid-Base Homeostasis with Aging

INTRODUCTION Acid-base disorders are commonly encountered in clinical practice and can have a substantial impact on a patient’s prognosis and outcome. The elderly are more prone to develop acid-base disturbances than the young. With age, the kidney undergoes structural and functional changes that limit the adaptive mechanisms responsible for maintaining acid-base homeostasis in response to […]