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Tag: Beyond

Beyond the Nomogram: Loading Doses

Among the current controversies regarding is the issue of dosing in the first few days, or the “loading phase” of therapy. Over the last 10 to 20 years, clinicians have moved away from the loading doses of 10 to 50 mg in favor of less aggressive “front-loading.”

Beyond the Nomogram: Drug Interactions

When patients are taking along with other medications, it is always prudent to identify and monitor them for possible pharmacokinetic and pharmacodynamic drug-drug interactions. Many reviews have covered the importance and character of these interactions. Some of the medications that have the potential to increase or decrease the effects of warfarin as a result of […]

Beyond the Nomogram: Pharmacokinetics and Pharmacodynamics

Vitamin K is contained in the phylloquinones in many green vegetables. It is also produced by bacteria from substrates within the intestinal tract and subsequently recycled enterohepatically as absorbable menaquinones. As vitamin K is absorbed from the intestine, it is stored in the liver for the production of clotting factors and anti-clotting proteins. Administration blocks […]

Beyond the Nomogram

Introduction For the past few decades in the U.S., cialis professional has become the oral anticoagulant of choice for treating or preventing thromboembolic events and for procedures associated with a substantial risk of thromboembolism. Despite the widespread prescribing of this medication, clinicians remain uncertain about how to best manage warfarin dosing.