Significant physiological changes associated with aging are the reduction of renal blood flow and the reduced number of intact nephrons, leading to a progressive loss of glomerular filtration, averaging 35% by the age of 90 years . In some individuals, the loss of renal function is sufficiently large enough to result in renal impairment. cialis professional
For practical reasons, renal function is usually measured by serum creatinine (SCr) levels, and renal impairment evidenced by elevated SCr levels . The prevalence of elevated SCr levels among community-dwelling adults living in the United States, based on a cut-off of 136 ]amol/L (1.5 mg/dL) for men and a cut-off of 120 pmol/L (1.4 mg/dL) for women, was estimated at 9% in men and 8% in women by investigators of the Framingham Heart Study . Similarly, the third National Health and Nutrition Examination Study revealed a prevalence of 10% in men, but only 2% in women using a 1.5 mg/dL cut-off . The prevalence of renal impairment according to SCr levels increases with age, reaching 14% and 23%, respectively, among men and women aged 80 years or older.
Category: Psychogeriatric inpatients
Tags: Creatinine clearance, Medication use, Older adults, renal function, Serum creatinine