Renal impairment and medication: RESULTS(1)

The mean age of the 37 patients present in both wards was 75.1 years (95% CI, 72.6 to 77.6), and 18 (49%) of the patients were women. Average weight was 69.7 kg (95% CI, 63.5 to 75.8). Eight patients (22%) had an organic mental disorder, 15 (41%) had a psychotic disorder, six (16%) had a mood disorder and eight (22%) had a personality disorder. The average SCr level was 89.3 pmol/L (95% CI, 81.1 to 97.5). Only one man had an SCr level above 136 pmol/L (150 mg/dL), and only one woman exceeded 120 pmol/L (140 mg/dL). buy levaquin online

According to CCr, 13 (35%) patients had moderate to severe renal impairment (CCr less than 50 mL/min). An additional six (16%) were borderline (CCr less than 55 mL/min). The Pearson correlation coefficient between SCr and CCr was -0.50 (P=0.002). A scattergram showing this relationship is provided in Figure 1. The coefficient of concordance (r2=0.25) suggested that the SCr levels and CCr could provide different pictures if data were dichotomized as ‘renal impairment’ versus ‘no renal impairment’. This prediction was supported by comparing the agreement between evaluations of renal impairment based on SCr levels and CCr. Although 13 patients were classified as renally impaired according to CCr data, only two of these patients were considered impaired according to SCr levels (k=0.19).

Figure1Renal impairment and medicatios
Figure 1) Relationship between serum creatinine (SCr) level and creatinine clearance (CCr)