Urinary Tract Infection (UTI) is common in women, elderly men, and children. Significant bacteriuria is taken as 105 organisms per millimeter of a fresh “clean catch” urine specimen in any patient. It indicates active infection of the urinary tract.
Kass was the first to highlight the importance of asymptomatic bacteriuria (AB)—he observed that 6 to 7% of pregnant women have AB and almost half of these develop pyelonephritis subsequently. AB also is of importance in the elderly and individuals who are known to be at high risk for recurrent symptomatic infection including diabetics, patients with cystic renal diseases, anatomic or neurologic urinary abnormalities and patients with a history of urethral catheterization. Untreated AB predisposes the individual to recurrent UTI, which cause considerable morbidity if complicated and can also cause severe renal disease.
Morbidity and mortality from UTI at all ages is still considerable. Patients with have an increased risk of infections, with UTI being the most prevalent infection. Serious complications of urinary infection, such as emphysematous cystitis, pyelonephritis, renal or perinephric abscess, bacteremia, and renal papillary necrosis occur more commonly in diabetic patients.
It has been postulated that both altered bacterial adhesion to the uroepithelium, due to abnormality of Tammhorsfal protein, and granulocyte dysfunction contribute to the pathogenesis of UTI in diabetics. Several polymorphonuclear defects, such as impaired migration, phagocytosis, intracellular killing, and chemotaxis, (which may be due to decreased polymorphonuclear membrane fluidity) occur in diabetic subjects. The pattern of AB has been studied in various populations. Although more controlled studies have examined the prevalence of bacteriuria in diabetic compared with nondiabetic subjects than any other infection, few workers have carried out similar work among diabetics in Nigeria. Of the highlighted studies, 75% reported a higher (two- to four-fold increase) bacteriuria prevalence in diabetic subjects. canada pharmacy mall
This study aims to investigate the prevalence of AB among Nigerian diabetic patients; document the susceptibility to AB among Nigerian diabetics, and to document the organisms’ responsible and antimicrobial sensitivity pattern of such organisms in this environment.