Weight Loss Category

Intimate desire of each woman: “Eat and not to get fat!”. Ways how to become well-shaped and to be always full are not magic, but quite real. In what does the slender secret consist? Slender secret – the proper snack or lay stomach for a while The situation when lunch is still far, and the […]

This assumption may be particularly important when one considers highly differentiated cells such as spermatozoa. In mature spermatozoa, the nucleus plays only a marginal, if any, role in modulation of their function, chromatin being condensed and little or no protein synthesis occurring during the life of mature spermatozoa. In these conditions, a nuclear translocation of […]

Despite the limitations of the published data, what literature was found in this review suggests that there is little justification for capping doses of LMW heparin. Most of the evidence reviewed here supports dosing based on total body weight. Others have drawn similar conclusions, whereas at least one group was less confident about drawing any […]

In evaluating the issue of dosing caps for LMW heparins, there is a paucity of data from which to draw conclusions. Assessment of this issue is dependent on data primarily from pharmacokinetic studies in healthy volunteers, post hoc or subgroup analyses from trials of acute coronary syndromes and venous thromboembolism, and small clinical trials using […]

Dosing of LMW Heparin in Obesity Indications Six trials were identified that documented dosing of LMW heparin in obese patients with venous thromboembolism and other indications. One of these trials compared once-daily and twice-daily nadroparin for treatment of this condition. In that study, patients weighing more than 90 kg each received 18 450 IU of […]

A Canadian study in a Quebec hospital followed patients given enoxaparin for a variety of indications (e.g., 33.5% of patients with atrial fibrillation, 22.7% with myocardial infarction, 20.6% with unstable angina). There was no maximum dose (i.e., no dose cap) for enoxaparin. Anti-Xa levels after 2-3 days of enoxaparin therapy were available for 214 patients, 81 […]

A review was conducted of English-language publications with information related to dosing and outcomes for obese patients receiving any of the 4 LMW heparins marketed in Canada. MEDLINE, PubMed, CINAHL (the Cumulative Index to Nursing and Allied Health Literature), and Interna­tional Pharmaceutical Abstracts (IPA) were searched with the following search terms: “low molecular weight heparin”, […]