Serum sickness Category

Terbinafine is extensively metabolized with 15 metabolites now identified. Eighty per cent of the dose is excreted in the urine so excretion of the drug and its metabolites is decreased in renal failure. Our patient demonstrated rather transient renal and car diac ab nor malities, so the car diac rhythm distur -bance may have been […]

Terbinafine is a fungicidal agent that acts by inhibiting the fun gal en zyme squalene ep oxi dase which is in volved in the synthesis of ergosterol, a component of the fungal cell wall. Terbinafine has generally been well tolerated with only minor adverse effects (Table 1). This is the first case of a severe […]

The patient was admitted to the intensive care unit and was treated with intravenous fluids, digoxin and procainamide. The terbinafine was discontinued. He converted to normal sinus rhythm within a few hours. On the second hospital day the patient became confused. His temperature was 39.1°C. On examination he had developed bitateral crepitations. Blood gas showed a […]

Terbinafine is an allylamine fungicidal agent that is active against a broad range of dermatomycoses. It is increasingly being used in the treatment of cutaneous dermatophyte infections. The majority ofreported adverse effects are mild, consisting of gastrointestinal events, skin reactions and malaise occurring in up to 11.4% of patients. Recently, more serious hematological adverse effects […]