Pulmonary Dysfunction Category

In a previous report, we found an association between HLA-DR4 and secondary Sjogrens syndrome with abnormal pulmonary function in patients with rheumatoid arthritis. This same association had been supported by other investigators. Radoux et al found that 80 percent of rheumatoid patients with airway dysfunction were HLA-DR4 positive and that a generalized abnormality of exocrine […]

The main finding in this study is that patients with rheumatoid arthritis who are HLA-DQwl positive have a significant reduction in pulmonary function compared to DQwl-negative individuals. The findings of a reduced FEVj, FVC, and D are consistent with an abnormal pattern of interstitial pulmonary disease in patients with rheumatoid arthritis who manifest the DQwl […]

Pulmonary Function Table 4 demonstrates the data on pulmonary function classified by the major DQw phenotypes. DQwl-positive patients had evidence of a restrictive ventilatory defect with a lower percentage of predicted FEVX, FVC, and D than DQwl-negative patients. DQw3-positive patients had evidence of an obstructive ventilatory defect with a lower FEVj/FVC than DQw3-negative patients. The […]

Clinical Data The clinical characteristics of the 47 patients grouped by major HLA-DQw status are shown on Tables 1, 2, and 3. DQwl-positive subjects included the phenotypes, DQwl/DQw-, DQwl/DQw2, and DQwl/DQw3. DQwl-negative subjects included the phenotypes DQw2/DQw-, DQw3/DQw-, and DQw2/ DQw3. Similar subclassifications were made for the presence of DQw2 and DQw3 alleles. There were […]

Laboratory Data Laboratory studies included complete blood cell count, platelet count, Westergrens erythrocyte sedimentation rate (ESR), rheumatoid factor by latex fixation, and antinuclear antibody. Chest roentgenograms were performed in all patients and were rated for the presence or absence of the following characteristics: hyperinflation; increased interstitial markings; pleural abnormalities; or localized scarring or atelectasis. Chest […]

Selection of Patients Patients were recruited for this study from a group of 89 outpatients with either classic or definite rheumatoid arthritis who had recently participated in a clinical drug trial. None of the subjects had previously received penicillamine or gold therapy prior to entry into the trial. Four patients with a history of asthma, […]

Rheumatoid arthritis is associated with several pulmonary manifestations, including pleural effusions, interstitial pulmonary fibrosis, intrapulmonary rheumatoid nodules, Caplans syndrome, and bronchiolitis obliterans. An increased prevalence of obstructive or restrictive ventilatory defects (or both) has also been found in patients with rheumatoid arthritis. The relationship of these abnormalities to smoking in these patients remains controversial. We […]