Pregnant Category

Our results demonstrate that a wide series of androgens are uteroactive agents by inducing relaxation in pregnant and nonpregnant human myometrium. This effect is consistent with previous reports in the isolated rat uterus, which show that the same androgens are also inhibitors of the myometrial contractility (reviewed by Perusquia ). These findings provide evidence that […]

Effects of Androgens on Spontaneous Myometrial Contractility DHEA and testosterone and its 5-reduced metabolites (5a-DHT, 5p-DHT, androsterone, and androstanediol) in the concentration range of 3.0-100 |xM inhibited the spontaneous contractions of pregnant uteri at term in a concentration-dependent manner. The relaxing effect of androgens, at all concentrations tested, was significantly different (P < 0.001) when […]

Drugs and Chemicals The following compounds were purchased from Sigma (St. Louis, MO): cholesterol (3p-hydroxy-5-cholesten), dehydroepiandrosterone (DHEA; 3p-hydroxy-5-androsten-17-one), testosterone (T; 17p-hydroxy-4-androsten-3-one), 5a-dihydrotestosterone (5a-DHT; 17p-hydroxy-5a-androstan-3-one), 5p-dihydrotestosterone (5p-DHT; 17p-hydroxy-5p-an-drostan-3-one), androsterone (3a,5a-androsterone; 3a-hydroxy-5a-andros-tan-17-one), androstanediol (3a,5a-androstanediol; 5a-androstane-3a,17p-diol), and progesterone (P; 4-pregnen-3,20-dione); the androgen receptor antagonist (flutamide), the protein synthesis inhibitor (cycloheximide), the transcription inhibitor (actinomycin D), cysteine, L-glutamine, penicillin-streptomycin […]

It is well documented that progesterone plays an essential role in reproductive events associated with establishment and maintenance of pregnancy. In this respect, it is widely accepted that progesterone elicits relaxation of uterine contractility and is the main basis of quiescence in myometrium during pregnancy. This action was described by Csapo as the progesterone block. […]