Medicine Help Category

Therein lies the greatest responsibility of guideline developers to rigorously analyze the evidence and base their recommendations on a grading system that explicitly describes the strength of the developed guidelines. In this way, clinicians can be provided with the least biased and most valid clinical recommendations achievable to allow them to apply selectively published guidelines […]

The difference, however, is in the understanding of evidence-based medicine and what it has to offer to patient care. Although the definition is undergoing evolution, evidence based medicine is the conscientious and judicious use of current best evidence from clinical care research in the management of individual patients. Conscientious use describes a clinician’s practice of […]

Realization that “expert opinion” is a form of “evidence” requires application of a formal consensus development method—as is done with the generation of other forms of scientific evidence—to guarantee that the final opinions will be valid, reproducible, and reliable. In this instance, the safeguards of a group process should be initiated so as to ensure […]

Expert opinion is also required to grade the evidence; grading methodologies are designed to minimize the opportunity for bias but cannot totally eliminate the role of expert judgments in applying the grading systems, weighting the relative limitations of different types of study design flaws, and resolving opinion differences in interpreting the strength of the data. […]

Following a formal method retains the link between the evidence and the final recommendations. A systematic and comprehensive literature search is the initial step for the members of the guideline panel. The literature search methods should be described in the final document to defend its reproducibility and completeness. The collected evidence is graded using one […]

Application of a formal guideline development process to produce guidelines with the abovedescribed attributes requires a methodologic approach. The first step centers on selection of an appropriate topic amenable to guideline development. Topics may pertain to a specific health condition (eg, pneumonia), a procedure (eg, bronchoscopy with BAL), or a process (eg, isolation techniques for […]

To avoid misapplication of clinical recommendations to the wrong patient populations or clinical settings, clinical practice guidelines should clearly state the specific patients and circumstances to which they apply. Appropriate clinical applicability is primarily determined by the scientific and clinical evidence. Guidelines may recommend, for instance, the use of fibrinolytic agents in patients with acute […]