Diffuse Panbronchiolitis Category

High concentrations of IL-8 and IL-1β were detected in BALF of DPB patients in the present study. Furthermore, the correlation between serum sL-selectin and BALF IL-8, and that between serum sE-selectin and the BALF IL-1β were significant in DPB patients. Cellular expression and shedding of E-selectin on endothelial cells are upregulated in vitro by various cytokines, […]

The present study demonstrated the presence of elevated serum levels of soluble adhesion molecules in patients with chronic neutrophil-mediated airway inflammation, particularly DPB. These results, together with those from other studies, suggest that accumulation of neutrophils in the airway of DPB patients results from infiltration of these cells from the circulation following a series of […]

Correlation Between Soluble Adhesion Molecules in Serum and Cytokines in BALF We measured IL-8 and IL-1β concentrations in BALF of healthy subjects and patients with DPB. The mean BALF concentration of IL-8 in DPB patients (344.7±238.0 pg/mL, n=25) was significantly higher than in healthy volunteers (4.3±3.7 pg/mL, n=ll, p<0.01). A significant correlation was observed in […]

Data were expressed as mean±SD. For comparison between groups, one-way analysis of variance (ANOVA) or paired t test was used. The correlation between two parameters was examined by Spearman’s rank correlation test. A probability of <5% was considered significant. viagra super active plus Results Serum Levels of Soluble Selectins The serum levels of sL-selectin in […]

Blood samples (10 mL) were collected between 6:30 and 7:00 am from each subject. Following centrifugation, 5 mL of serum w8ls frozen at — 20°C for later analysis. On the day of the test, a standard BAL was performed as described previously. Briefly, after local anesthesia of the upper airway with 4% lidocaine, a flexible […]

Diffuse panbronchiolitis (DPB) is characterized by chronic inflammation, localized predominantly in the respiratory bronchioles, with infiltration of inflammatory cells, such as mononuclear and plasma cells. A high number of neutrophils and activated T lymphocytes are present in the airspaces, and accumulation of the former group has been implicated in the pathogenesis of DPB. Recent advances […]