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To our knowledge, this is the first systematic investigation to describe the prevalence of warfarin and antiplatelet combination therapy within a commercially insured patient population managed by an anticoagulation service. Results of this investigation suggest that this practice is widespread in anticoagulation management care: approximately 4 of 10 patients surveyed were receiving warfarin and antiplatelet […]

A total of 6,015 patients were identified as receiving warfarin pharmacotherapy as of September 30, 2005. Of these patients, 16 were excluded for receiving warfarin as VTE prophylaxis following an orthopedic surgery. An additional 1,442 patients were excluded due to as-yet undocumented aspirin use or nonuse. Thus, a total of 4,557 patients were included in […]

Both warfarin and antiplatelet medications (eg, aspirin, clopidogrel) have established efficacy for prevention of primary and secondary ischemic events. Given different mechanisms of action, combining these agents holds the potential for additive and perhaps even synergistic reductions in thromboembolic morbidity and mortality. Conversely, for some patients, combination therapy may increase the risk of clinically significant […]

Cluster Analysis of Cases During the study period, TB was diagnosed in 390 case patients in Boston. Of these, 328 patients had a positive culture for M tuberculosis. Seven case isolates were not available for RFLP typing, leaving 321 cases for analysis. Of these, 188 (58.6%) were not clustered and 133 (41.4%) were clustered. In […]