Benzodiazepines Category

A lack of follow-up also prevents the use of formal ADR causality assessment methods because much of the data required by these methods, eg, information about dechallenge or rechallenge, are usually not available from health care utilization databases, especially when supplied in aggregate form as was done in this study. If the data had been […]

The significant frequency of injuries in the first period in both drug groups may be related to the occurrence of dizziness and vertigo. Other disorders, especially cardiovascular conditions, that were significant in the lorazepam patients tended to occur in the elderly (Table 4) and may be related to the slight preponderance of older patients in […]

Because the age, sex and treatment continuation distributions of the alprazolam and lorazepam patients are similar, differences observed in rates of events are unlikely to be due to these characteristics. However, it should be remembered that the reasons for the benzodiazepines being prescribed were not identified and may be differently distributed among the two groups. […]

In both tables, the rates of dizziness or vertigo, respiratory symptoms, esophagus and stomach disorders other than peptic ulceration and gastrointestinal hemorrhage, female genital organ disorders, inflammatory skin conditions, injuries, and ill-defined signs and symptoms were significantly greater in the first 30-day period after the initial prescription than in the following six. In addition, significantly […]

A similar male to female distribution was observed in the two drug groups, 32.6% to 67.4% for alprazolam and 33.1% to 66.9% for lorazepam. The lorazepam patients were slightly older than the alprazolam patients, with 25.9% and 20.9%, respectively, being 65 years of age or older. Only about a third of both groups of patients […]

The methodology of the scheme has been described in detail elsewhere and is, thus, only outlined here. The general principle is to identify the first 20,000 patients dispensed the new drug and to extract all medical ‘events’ recorded for these patients in the datafiles after the initial prescription while they remain on the medication. An […]

The linkage of administrative health care utilization databases offers advantages for postmarketing surveillance. The data have already been collected , and, although such data systems are not ideal for research purposes and need careful evaluation to ensure adequate data quality , they usually do not suffer from problems arising from a significant nonresponse. Saskatchewan has […]