Asthma Category

Neither atenolol nor celiprolol affected daily asthma control and inhaler use in our study. Four conditions of the study need to be borne in mind: (1) the dose and duration of beta-blockers used; (2) the small number of subjects studied; (3) the mild nature of their asthma; and (4) the absence of events such as […]

In this study on a small group of selected patients Adth coexisting hypertension and asthma, a singledose challenge with atenolol, 100 mg, caused bron-choconstriction in most subjects, while the response to single-dose challenge with celiprolol, 400 mg, closely resembled that with placebo. Without the sustained bronchodilator benefit of beta-2 agonists during the preceding 10-h period, […]

Adverse effects were mild and most occurred during the placebo phase. Two patients complained of tiredness and mild ankle swelling, and another had headaches while taking atenolol. Blood Pressure and Pulse Rates All diastolic blood pressures fell significantly during both celiprolol and atenolol treatment, but systolic blood pressure taken with the patient in a supine […]

During each phase of the study, including the run-in period, patients recorded the following on diary cards: 1. Symptom scores of cough and dyspnea during the preceding 12 h (twice daily recordings). Cough was scored as follows: (a) no cough, (b) occasional cough, (c) bad cough— intermittently, (d) bad cough most of the time. Dyspnea […]

Patients were permitted to use their usual bronchodilator therapy throughout the study (Table 1) except during the 10-h period before a clinic visit. No antihypertensive agents other than the trial medications were allowed. Throughout the 12-week study, patients had 24-h telephone access to a doctor, and were encouraged to report even minor changes in respiratory […]

The danger of using beta-adrenergic blockers and particularly those without cardiac selectivity in asthmatic patients has been known for more than 20 years. Even relatively cardioselective agents (including atenolol) have been shown to produce significant bronchoconstriction, and for this reason are strictly contraindicated in asthma. One possible way of overcoming the adverse effects of beta-blockade […]

The failure to observe a fall in ventilation after methacholine challenge is not likely to result from our use of the Respitrace, since this device tended to underestimate the tidal volume changes following induced bronchoconstriction. It thus seems likely that much of the hypoxemia resulted from changes in the distribution of alveolar ventilation to perfusion […]