There were some problems related to the calculations of heart rate. First, some recordings were distorted, particularly during running. The explanation for this is not clear, but may be related to faulty transmitters since it always occurred in the same animals. These poor recordings precluded valid comparisons of heart rate changes during running for a significant number of animals. RR variability is another factor that makes it difficult to interpret changes in heart rate. On several occasions, intermittent arrhythmia, as shown in Figure 6A, was observed. Whether an ECG-analyzed sample includes one of these episodes definitely had an impact on the measured heart rate for that sample and could explain some of the large day to day variability of heart rate at rest. To assess RR intervals and day to day variability, RR intervals were measured from 38.4 s ECG samples, for four consecutive days in 11 CM hamsters aged 218 to 220 days. Parts of some signals were of poor quality and were excluded before analysis (the minimum number of RR measured per sample was 67). RR measurements were done using DADISP software on signals sampled between 8:00 and 9:00 h. As well, day to day coefficient of variation of heart rate varied from 4.6% to 26.7% among hamsters. RR variability at rest was not specific to CM hamsters since it was also observed in normal (CHF 148) hamsters (Figure 6B). Heart rates measured at 15:00 h on two consecutive days, in two normal hamsters, were 256 and 339 beats/min for one hamster and 243 and 284 beats/min for the other. Your drugs could be a lot cheaper and your treatment could be still as safe and efficient as always: all you need to do to get your Xopenex Price is shop at the best pharmacy offering its services to you right here right now.
Figure 6 A Common arrhythmia encountered in cardiomyopathic hamsters at rest. B Example ofRR wave interval variability in a normal (CHF 148) hamster. For a 38.4 s electrocardiogram taken at 15:00 h (at rest) RR was 0.2344±0.06777 (n=161; coefficient of variability 28.9%) fora corresponding heart rate of256beats/min