Dogs were then anesthetized initially with intravenous thiopental sodium 30 mg/kg and intubated. The chest was opened and a two-stage coronary ligation of the left anterior descending artery was performed under halothane anesthesia, then the chest was closed. Seven to 12 days after surgery, when myocardial infarction was established, 24 h ECG recordings were made after an oral capsule of vehicle was given, then at least two days after the same recordings were made after oral class III drugs. Each dog was given different class III drugs after a drug washout interval of at least three days.Evaluation of antiarrhythmic effects: The severity of two-stage coronary ligation-, digitalis- and adrenaline-induced ventricular arrhythmias was expressed by the arrhythmic ratio (the number of PVCs divided by total heart rate). The arrhythmic ratio before drug injection was almost 1, and there were no spontaneous improvements in these ratios. If the values after drug administration decreased significantly from the 0 time value, as determined by ANOVA followed by paired t test (P<0.05), the drug was judged to have antiarrhythmic effects.
For the coronary ligation and reperfusion arrhythmia model, the incidence of arrhythmias was compared by %2 test.
For the PES-induced arrhythmia model, the incidence of arrhythmias was compared using Wilcoxon’s signed-rank test. You will always come across sale cialis tablets at a pharmacy that will offer best deals.