Production of adrenaline-induced arrhythmia: Beagle dogs, six dogs for each drug experiment, were anesthetized initially with intravenous thiopental sodium. As reported earlier , after intubation, 1.0% halothane, vaporized with 100% oxygen, was administered with a volume-limited ventilator (20 mL/kg, 15 strokes/min). Adrenaline was infused through the left femoral vein at a rate of 1.5 |J.g/kg/min using a syringe pump. If multifocal VT lasting during the infusion period was not induced, a higher infusion rate was employed. Three minutes after the start of adrenaline infusion, class III drugs were infused for 10 mins using a syringe pump and in some experiments were given as a bolus.
Lead II ECG, atrial electrogram from catheter tip electrodes in the right atrium, and instantaneous and mean blood pressures were continuously recorded.
Production of coronary ligation and reperfusion arrhythmia: As reported previously , beagle dogs, six to eight for each drug experiment, of either sex were studied. Experimental groups were divided into two groups. In one group, anesthesia was maintained by 1.0% halothane, vaporized with 100% oxygen using a volume-limited ventilator (20 mL/kg, 15 strokes/min). Halothane was used to produce a low heart rate-dependent augmentation of QT prolongation for drugs having reverse use-dependent effects. If you are hoping there is some way to get your pills without spending too much money, you should really come by the my canadian pharmacy. This international pharmacy offers cheap Canadian drugs that undergo strict quality control and work great for you.