Although our study does not reveal mechanisms of antiarrhythmic effects of class III drugs, some differences among these drugs on canine ventricular arrhythmias were revealed. This suggests the existence of electrophysiological differences among individual drugs and possibly differences in their clinical usefulness. The most prominent difference shown in Table 1 is that amiodarone given intravenously is effective for automaticity arrhythmias. This may indicate that amiodarone also has sodium and calcium channel blocking effects that are more prominent than potassium channel blocking effects when given acutely .Further development of class III drugs should be supported by animal models not only to predict antiarrhythmic effects of drugs, but also to reveal proarrhythmic effects. For the moment, class III drugs have been shown to be effective in suppressing reentry arrhythmias and to have positive inotropic effects, or at least no negative inotropic effect commonly observed in other class I, II and IV drugs. They are likely, therefore, to be efficacious in preventing selected arrhythmias due to reentrant mechanism, occurring especially in patients with previous myocardial infarction. Choose a perfect online pharmacy to get cheap alesse buy here and treat your health issue.