Prostate cancer is the most frequently diagnosed cancer and is second only to lung cancer as the leading cause of cancer-related deaths among American men. It is estimated that nearly 29,000 American men will die of prostate cancer each year. Of these men, African-American men are proportionately the most severely affected. Between 1992 and 1999, the yearly prostate cancer incidence for African-American men was 275.3 (per 100,000) compared with 172.9 for Caucasians and 127.6 for Hispanics. Furthermore, African-American men had a higher incidence of metastases at presentation (13%) compared with Caucasian men (8%) and yearly prostate cancer mortality (75.1 per 100,000) exceeding twice that of Caucasian (32.9) and Hispanic (22.6) patients.
Few studies have evaluated the relationship among race, prognostic factors and survival in men who have progressed to androgen-independent prostate cancer (AIPC). Fowler and colleagues reported their experience treating 524 African-American men with of various pathologic stages. No differences in overall or cause-specific survival were identified between 181 African-American men with metastatic prostate cancer and 74 matched Caucasian men. Optenberg and associates analyzed prostate cancer presentation and progression in 1,606 patients from an equal-access military health system, which included 120 African-American men. Although the African-American men with prostate cancer were younger, presented with a higher stage and progressed to metastatic disease more rapidly than did Caucasian men, there was a trend for improved survival in African-American men with distant metastatic disease. canada drugs online
In an effort to increase our understanding of AIPC behavior in different racial and ethnic groups and to identify prognostic variables affecting survival, we retrospectively reviewed our experience in the management of patients with AIPC.