Gastric cancer


Porokeratosis is a group of disorders of keratini- zation that is characterized histologically by a para- keratotic column in the center of a keratin-filled invagination, called a cornoid lamella. Clinically, the basic lesion is sharply demarcated and hyper- keratotic with central atrophy. The pathogenetic mechanism of porokeratosis is still unknown, but porokeratosis is known as genetically heterogeneous disorder associated with UV light, trauma, infection, and immunosuppression. Besides the classical poro­keratosis of Mibelli, there are also five clinical variants: porokeratosis palmaris et plantaris disse­minata (PPPD), linear porokeratosis, punctate porokeratosis, disseminated superficial porokeratosis (DSP), and disseminated superficial actinic poro- keratosis (DSAP), all of which may be inherited by autosomal dominant mode.

DSP is a rare variant and is characterized by asymptomatic, small, annular papules that involve the trunk, genitalia, palms, and soles. Lesions range from 2 to 5 mm in size and an excess of 100 lesions may be present, but do not spare sun-protected area as in DSAP. The histological typical features of porokeratosis, cornoid lamella and vacuolated kera- tinocytes, are less pronounced in DSP than in classical porokeratosis of Mibelli. In many cases of DSP, the presence of immunosuppression has been an eliciting factor.
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We report an unusual case of disseminated super­ficial porokeratosis in a patient with gastric cancer.