The results of PFTs were within normal range in both groups of children. Twenty-one of the 24 children of asthmatic parents responded to 1.0 mg of metha­choline per inhalation with a mean bronchial sensitiv­ity of 2.2 ± 1.1 mg of methacholine and a mean bron­chial reactivity of 6.5 percent ± 4.5 percent decrease in SGaw per milligram of methacholine (Fig 1).

Table 1 — Bronchial Response in Children of Asthmatic Barents with and without Atopy

No.

Mean Bronchial Sensitivity, mg

Mean Bronchial Reactivity, Percent Decrease in SGaw/mg

Allergic

8

1.3 ±0.5»

10.5 ±5.0*

rhinitis

No atopy

13

2.7± 1.1*

4.8± 1.7*

FIGURE 1 . Mean and standard

FIGURE 1. Mean and standard deviation of dose response regression line for “healthy” children of asthmatic parents and healthy children of healthy parents.

Three children of asthmatic parents did not respond even to 15.0 mg of methacholine. One child of healthy parents responded with a decrease of 40 percent in SGaw after 13.0 mg of methacholine with no farther decrease until a dose of 15.0 mg. Eight of the 21 children with airway hyperreactivity suffered from allergic rhinitis. Their bronchial sensitivity and reac­tivity were twice as high as in the 13 nonatopic children of asthmatic parents (p<0.05) (Fig 2, Table 1). buy levitra 20 mg

Table 2—Effect of Cromolyn Sodium on Bronchial Response to Methacholine

Before Cromolyn Sodium

After Cromolyn Sodium

Mean Bronchial

Mean Bronchial

Mean Bronchial

Reactivity,

Mean Bronchia]

Reactivity,

Sensitivity,

Percent Decrease

Sensitivity,

Percent Decrease

No.

mg

in SGaw/mg

mg

in SGaw/mg

Children with atopy

8

1.3±0.5*

10.5 ±5.0*

3.7±2.1*

3.4 ±1.3*

Children without atopy

5

2.1 ±0.9t

5.0± l.lt

2.1 ±0.9t

4.9±1.6f

FIGURE 2. Individual dose response

FIGURE 2. Individual dose response regression lines for “healthy” children of asthmatic parents. Lines with dots represent children with allergic rhinitis.

In eight atopic children both bronchial sensitivity and reactivity decreased significantly (p<0.05) after six weeks of treatment with cromolyn sodium, while no change was observed in bronchial sensitivity and reactivity in five nonatopic children (Fig 3, Table 2) and in two children without treatment.
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FIGURE 3. Mean and standard

FIGURE 3. Mean and standard deviation of the dose response regression lines for children of asthmatic parents before and after treatment with cromolyn sodium.